home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9605a.zip
/
M9650352.TXT
< prev
next >
Wrap
Text File
|
1996-03-09
|
2KB
|
33 lines
Document 0352
DOCN M9650352
TI Computer simulations to predict the availability of peptides with known
HLA class I motifs possibly generated by proteolysis of HIV-1 proteins
in infected cells.
DT 9605
AU Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew;
University of Jerusalem, Israel.
SO Virus Genes. 1995;10(3):227-37. Unique Identifier : AIDSLINE
MED/96124518
AB Cytotoxic T cells that recognize HIV-1 peptides generated from all viral
proteins were reported. To predict the cleavage pattern of HIV-1
proteins by cytoplasmic proteasomes into peptides with motifs fitting
known HLA class I molecules, the computer program Findpatterns was used.
In this paper the combined amino acids patterns for proteolytic
cleavages and the HLA class I haplotype-restricted peptides motifs are
studied. It was noted that peptides with motifs of HLA class I A2 and
A68 were abundant compared with HLA class 5B2, B8, B53, and B35.
DE Amino Acid Sequence Amino Acids/METABOLISM Antigen Presentation
*Computer Simulation Cysteine Proteinases/METABOLISM
Histocompatibility Antigens Class I/*IMMUNOLOGY Human HIV
Protease/METABOLISM HIV-1/*IMMUNOLOGY Molecular Sequence Data
Multienzyme Complexes/METABOLISM Peptide
Fragments/IMMUNOLOGY/METABOLISM Peptide Peptidohydrolases/METABOLISM
Software Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
Viral Nonstructural Proteins/IMMUNOLOGY/METABOLISM Viral
Proteins/*IMMUNOLOGY/METABOLISM Viral Structural
Proteins/IMMUNOLOGY/METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).